Vijay + Gautam..!

Vijay will be playing 'Your' film series, A. R. Played, video and data images that appear to act in any film from the side that's not been confirmed.

In the News - Gautam Menon film is confirmed. Yohan - Chapter One (the first goal: New York) is named.

In the Post this morning, 'Action Est 2012' said. A film. R. Ceyyapatalam Rahman's music seems to be agreement.

Gautam Menon is producing the film through his company hpoton katas. Since the start of next year's film, 'Your film work is cast in the movie, who would have finished viewing the question in Kodambakkam

By 24X7 News with No comments

Simbu Ajith in style!

Extreme fan of the actor Simbu Ajith in Tamil film actors.
Cilampattam film starring Ajith in' Billa ', like a film set for some scenes Sky at the film premiere of 'Hello Thala Thala' Ajith's fan saying that he proved again and again.

Ajith starrer 'Audio Launch' has already started shooting for Ajith fans get ready to be released special TEASER. Your image in his performance it would be like 'king of the hunt' for a movie made that one published TEASER alone.

That 'Audio Launch' film TEASER-Like 'Hunt of King' s TEASER-m were prepared. If in the future, the remake of Ajit's films deal with the first answer to the question of who is going to be out ..!

By 24X7 News with No comments

Obesity may disrupt circadian clock in cardiovascular system

It's known that obesity may lead to heart disease. But for the first time scientists have found evidence of how exactly that happens - by shutting down the "clock" that regulates the cardiovascular system.

The body has a circadian or biological clock that helps it adapt to the day/night cycle. Individual cells also have circadian genes, a molecular clock, to help individual tissues adapt to patterns.

But in obese individuals, who frequently eat at irregular times, the natural circadian rhythms are believed to be disrupted and it may lead to several metabolic disorders like hormonal imbalance, psychological and sleep disorders, as well as cancer. People working in shifts are likely to suffer from such problem.

With obesity known to affect at least the eat/sleep cycles, a team at the Georgia Health Sciences University in Augusta in the US set out to determine whether obesity might also affect the molecular components of the clock that governs the vascular system - the system of the heart and blood vessels that are responsible for blood movement in the body.

Their research, presented at the Experimental Biology 2011 meeting in Washington, was conducted in two phases.

In phase one, they examined the circadian variation in the cardiovascular chamber of three groups of mice (lean, obese and diabetic) at three time intervals: early morning, mid-day and evening, and measured the gene expression in the cardiovascular genes during these times.

Evidence of a cardiovascular rhythm was found in the lean animals. Among the evidence was the presence of endothelial nitric oxide synthase (eNOS), an enzyme helps coordinate blood flow, thus tends to be elevated at the end of the day and lower in the morning.

But, the researchers found this rhythm was lost in obese animals. For example, eNOS had either shifted its pattern, peaked at the wrong time, or was flat overall. Thus, the obese animals had lost their ability to control circadian variation of eNOS.

In phase two, the team used the data to examine whether the lack of rhythmic response could translate into a cardiovascular defect. They did so by examining a series of specific molecules from the cardiovascular clock genes and by measuring the acceleration of the genes in the blood vessels.

While in the lean animals they found that a key regulator of circadian rhythm, a gene called Clock, was high in morning and low in evening, the expression of the gene remained flat throughout the 24-hour cycle in the obese animals.

Dr David Stepp, a senior researcher on the team, summed up the findings by saying, "Based on the results of this study we now know that obesity impairs the clock machinery of the vasculature system and that correlates with a variation in expression of cardiovascular genes and their loss of the circadian rhythm."

By 24X7 News with No comments

Wonder Woman Mother Good Health Story Now, a nasal spray to spell the end of flu jab!

Scientists claim to have created a nasal spray that is even more effective against disease than an injection, a breakthrough which could spell the end of the flu jab.

The spray works by building up resistance to disease in the nasal passages and stopping the infection taking hold in the body, according to the scientists from Albany Medical College in New York.

Until now nasal vaccines have not offered enough protection to be effective and jabs have remained the most common form of building up immunity. But the new study shows how including a natural immune chemical with standard vaccines can boost their protective effect when delivered via the nose. Combining standard vaccines for respiratory pathogens with the immune chemical, interleukin-12 (IL-12) and delivering them intra-nasally to mice has been shown to induce high levels of protection, 'The Daily Telegraph' reported.

Vaccines against various respiratory pathogens were tested, including influenza virus, pneumococcal bacteria and Yersinia pestis, a bacteria used in bio-weapons. IL-12 is a natural immune chemical, known as a cytokine.
It is a powerful stimulator of the immune response through its interactions with other immune chemicals and the white blood cells that produce them, say the scientists.

Prof Dennis Metzger, who led the study, said: "Infectious agents still account for around 25 per cent of deaths worldwide and the major killers are acute respiratory infections. "However, it is difficult to induce immunity at the site of entry and so standard vaccines are only partially protective. Intranasal vaccination gets around this problem by inducing immunity in the pulmonary passage. This prevents initial infection as well as systemic complications." He added: "Vaccination via a nasal spray is a non-invasive procedure that is easier than administering vaccines by injection."

By 24X7 News with No comments

4 apples daily cut cholesterol

It's said an apple a day keeps the doctor away. Now, scientists say there is some truth in the old adage as they found the fruit helps cut cholesterol levels and lose weight significantly.

Researchers at the Florida State University in the US found that women who ate 75 grams of dried apple a day for six months saw levels of LDL cholesterol -- the harmful form blamed for clogging arteries -- fall by almost a quarter. Levels of other compounds linked to heart disease and strokes also dropped, and amounts of HDL or "good" cholesterol that wards off the hardening of blood vessels rose by about four per cent, the Daily Mail reported.

The women also lost an average weight of just over three pounds, despite taking on an additional 240 calories a day from snacking on the fruit. The cholesterol benefits are said to have been triggered by apples' anti-oxidants, while the slimming effect has been attributed to a compound which can suppress appetites.

Pectin is often used to help jams set, and high levels are also found in apricots, carrots and citrus fruits. Getting the equivalent benefits from fresh apples would require eating four or five a day, the researchers said. Dr Bahram Arjmandi, who led the study, said he "never expected apple consumption to reduce bad cholesterol to this extent", adding that the results were "incredible".

"Everyone can benefit from consuming apples," Dr Arjmandi told the Experimental Biology conference in Washington. Although the tests focused on dry fruit, help is at hand for fans of the fresh variety with the recent decoding of the apple's genetic code, paving the way for crunchier, juicer and healthier produce.

Scientists are already using the information to create "extra-healthy" apples, set to reach supermarket shelves within four or five years. Teams are breeding red-fleshed apples bursting with nutrients said to do everything from protecting eyes and joints to warding off heart disease, cancer, Alzheimer?s disease and diabetes.

By 24X7 News with No comments