Scientists claim to have created a nasal spray that is even more effective against disease than an injection, a breakthrough which could spell the end of the flu jab.
The spray works by building up resistance to disease in the nasal passages and stopping the infection taking hold in the body, according to the scientists from Albany Medical College in New York.
Vaccines against various respiratory pathogens were tested, including influenza virus, pneumococcal bacteria and Yersinia pestis, a bacteria used in bio-weapons. IL-12 is a natural immune chemical, known as a cytokine.
It is a powerful stimulator of the immune response through its interactions with other immune chemicals and the white blood cells that produce them, say the scientists.
Prof Dennis Metzger, who led the study, said: "Infectious agents still account for around 25 per cent of deaths worldwide and the major killers are acute respiratory infections. "However, it is difficult to induce immunity at the site of entry and so standard vaccines are only partially protective. Intranasal vaccination gets around this problem by inducing immunity in the pulmonary passage. This prevents initial infection as well as systemic complications." He added: "Vaccination via a nasal spray is a non-invasive procedure that is easier than administering vaccines by injection."
Sunday, April 24, 2011
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